منابع مشابه
Towards resolving the transcription factor network controlling myelin gene expression
In the central nervous system (CNS), myelin is produced from spirally-wrapped oligodendrocyte plasma membrane and, as exemplified by the debilitating effects of inherited or acquired myelin abnormalities in diseases such as multiple sclerosis, it plays a critical role in nervous system function. Myelin sheath production coincides with rapid up-regulation of numerous genes. The complexity of the...
متن کاملMapping of Transcription Factor Binding Region of Kappa Casein (CSN3) Gene in Iranian Bacterianus and Dromedaries Camels
κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...
متن کاملMapping of Transcription Factor Binding Region of Kappa Casein (CSN3) Gene in Iranian Bacterianus and Dromedaries Camels
κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...
متن کاملCalculating transcription factor binding maps for chromatin
Current high-throughput experiments already generate enough data for retrieving the DNA sequence-dependent binding affinities of transcription factors (TF) and other chromosomal proteins throughout the complete genome. However, the reverse task of calculating binding maps in a chromatin context for a given set of concentrations and TF affinities appears to be even more challenging and computati...
متن کاملBioinformatics Approach for Transcription Factor Binding Properties
A random forest classifier for transcription factor binding properties. (Fig. 1). O ne of the central questions in molecular genetics regards the mechanisms of transcriptional regulation , particularly how transcription factors (TFs) regulate expression of target genes with specific TF binding sites (TFBSs). Identifying TFBSs would permit a more comprehensive and quantitative mapping of the reg...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2011
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3153